Agalsidase Beta (Fabrazyme)

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General Information

Agalsidase Beta (Fabrazyme) is indicated for use in patients with Fabry disease. It is a rare genetic disease with a deficiency of an enzyme called alpha-galactosidase A. This condition affects many parts of the body such as:

  • Heart
  • Brain
  • Kidney
  • Eyes
  • Skin
  • Nervous system
  • Gastrointestinal system

Agalsidase Beta is intended for intravenous infusion. This is supplied as a sterile, nonpyrogenic, and white to off-white.

Why use Agalsidase Beta (Fabrazyme)?

Agalsidase Beta (Fabrazyme) is a recombinant human α-galactosidase-A enzyme. It is the same with the amino acid sequence as the native enzyme. This medicine contains Fabrazyme. It reduces globotriaosylceramide (GL-3) deposition in capillary endothelium of the kidney and certain other cell types. The Food and Drug Administration (FDA) has approved this medication. You can buy this here at its very affordable price. 

How does Agalsidase Beta (Fabrazyme) work?

Agalsidase Beta (Fabrazyme) is intended to provide an exogenous source of α-galactosidase-A. Clinical and non-clinical studies evaluating a limited number of cell types had an indication. It is that Agalsidase Beta (Fabrazyme) will catalyze the hydrolysis of glycosphingolipids including GL-3. Fabry disease is an X-linked genetic disorder of glycosphingolipid metabolism. 

How to use Agalsidase Beta (Fabrazyme)?

The suggested dose for this treatment is 1mg/kg. It is infused every two weeks as an intravenous infusion. The initial intravenous infusion rate is not more than 0.25mg/min. The maximum rate for patients weighing less than 30kg is 0.25mg/minute. If you do not know how to use this treatment, seek for doctor’s assistance. If he/she gave you a dosing instruction, follow it very carefully. 

What are the side-effects of Agalsidase Beta (Fabrazyme)?

Here are some possible side effects that may occur while using this treatment:

  • Hives
  • Skin rash
  • Flushing (redness, warmth, tingly feeling)
  • Chest discomfort
  • Trouble swallowing
  • Difficult breathing
  • Feeling light-headed
  • Swelling of your lips, face, tongue or throat
  • Nausea
  • Vomiting
  • Diarrhea
  • Muscle and back pain
  • Dizziness
  • Pale skin
  • Stuffy nose

If these persist or worsen, seek medical assistance right away.

Warnings and Precautions

  • Before using this, tell your doctor if you have allergies, medical history or current medications.
  • Consult first your doctor if you are pregnant or breastfeeding women.
  • This may make you feel dizzy. Avoid driving or perform an activity that needs your alertness.
  • Do not share this with others who have the same condition as yours.
  • Keep at a clean place to avoid infection.
  • Keep this away from the reach of children.