Iclusig (Ponatinib)

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General Information

Iclusig (Ponatinib) is indicated for the treatment of certain blood cancer:

  • Acute lymphoblastic leukemia (ALL)
  • Chronic myelogenous leukemia (CML)

ALL is a type of cancer in which the bone marrow makes too many immature lymphocytes. It may affect platelets, red and white blood cells.

CML is a disease in which the bone marrow makes too many white blood cells. It is a slowly progressing blood and bone marrow disease. It usually occurs during or after middle age and rarely occurs in children.

How does Iclusig (Ponatinib) work?

Iclusig (Ponatinib) is designed to block tumor cell development in some ways. This medication targets several proteins called tyrosine kinases. It is on the surface of cancer cells, as well as targets within the cell. Some of these targets are thought to be involved in angiogenesis or the making of blood vessels.

Why use Iclusig (Ponatinib)?

Iclusig (Ponatinib) belongs to the class of medications called kinase inhibitors. It contains an active ingredient of Ponatinib. It is off-white to yellow powder. It comes as a tablet with 15 mg, 30 mg, and 45 mg for oral use. Each tablet is available as white and round film-coated. The Food and Drug Administration (FDA) has already approved this prescription.

How to use Iclusig (Ponatinib)?

The dosage is based on your medical condition and response. It is important to take it exactly as it is prescribed. Do not take more than or more often than the prescription.

It is to be taken by mouth with a full glass of water. It is usually taken once a day. Swallow the tablet as a whole. Do not break or chew it. Do not lie down for about 10 minutes after taking a dose. If stomach upset occur, you may take it with food, milk, or an antacid.

What are the side-effects of Iclusig (Ponatinib)?

  • Stomach or abdominal pain
  • Skin rash
  • Headache
  • Tiredness
  • Dry skin
  • Joint pain
  • Constipation
  • Nausea
  • Fever

If these side effects persist or worsen, call for medical help right away.

Warnings and Precautions

  • Before taking this medication, tell your doctor if you are allergic to it. This drug may have an inactive ingredient that causes an allergic reaction.
  • Inform your doctor if you have any medical history or current medications or treatments. 
  • This drug may make you feel dizzy. Do not use any machinery or do anything that requires your alertness.
  • Do not twice the prescribed dosage to avoid some other complications.