Lesinurad and Allopurinol

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General Information

Lesinurad and Allopurinol are used to lower uric acid. The effect of this medication is to help prevent gout flares or attacks. Increased uric acid levels can cause gout attacks.

Gout is a form of inflammatory arthritis that develops in some people who have high levels of uric acid in the blood. The acid can form needle-like crystals in a joint and cause severe episodes of pain, redness, swelling, and tenderness.

How do Lesinurad and Allopurinol work?

Lesinurad and Allopurinol inhibit xanthine oxidase. It is the enzyme that converts hypoxanthine to xanthine to uric acid. Inhibition of this enzyme is responsible for the effects of this medication. This drug increases the utilization of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis. It is by a process that involves the enzyme hypoxanthine-guanine phosphoribosyltransferase.

This progression results in an increased nucleotide concentration that causes feedback inhibition of de novo purine synthesis. The end result is decreased urine and serum uric acid concentrations, which decreases the incidence of gout symptoms.

Why use Lesinurad and Allopurinol?

Lesinurad and Allopurinol is a combined medication that helps lessen the amount of uric acid that your body makes. This also helps the kidneys get rid of uric acid. This is a prescription approved by the Food and Drug Administration (FDA). Lesinurad is a URAT1 inhibitor and Allopurinol is a xanthine oxidase inhibitor. This medication is available as a tablet with 200 mg and 300 mg of Lesinurad and Allopurinol.

How to use Lesinurad and Allopurinol?

The recommended dosage is based on your medical condition and response. It is important that you take this prescription exactly as it is given. Do not take more or less than recommended.

This is to be taken by mouth. Swallow the tablet as a whole with a full glass of water. This is usually taken once a day in the morning. Drink plenty of fluids while taking this drug. Remember to take it at the same time every day.

What are the side effects of Lesinurad and Allopurinol?

  • Headache
  • Skin rash
  • Chest pain or discomfort
  • Confusion
  • Double vision
  • Nausea
  • Sweating
  • Vomiting
  • Sweating
  • Slow speech
  • Pain or discomfort in the arms, back, jaw, or neck

Warnings and Precautions

  • Do not stop taking this medication without consulting your doctor.
  • Tell your doctor if you are allergic to it. Tell also if you have any allergies.
  • This drug may make you drowsy. Do not drive or use any machinery that needs your alertness.
  • While taking this medicine, limit alcoholic beverages.
  • His should not be used during pregnancy. If you are breastfeeding women, consult your doctor first.
  • Let your doctor know if you ever had a stroke, liver disease, or high blood pressure.