Alefacept (Amevive)

General Information

Alefacept (Amevive) is indicated for the treatment of adult patients with moderate-severe chronic plaque psoriasis. Those are the candidates for systemic therapy or phototherapy. This reduces immune cell counts which could increase the chance of developing malignancy or infection. This is available in either intravenous injection (7.5mg) or intramuscular injection (15mg) formulations. 

Why use Alefacept (Amevive)?

Alefacept (Amevive) is an immunosuppressive dimeric fusion protein. It reduces lymphocyte counts (T-cells) thus treating the cause of psoriasis. This is supplied as a sterile, white to off-white, and preservative free. This is lyophilized powder as well for intramuscular administration. The Food and Drug Administration (FDA) has approved this medication. You can buy this here at its very affordable price. 

How does Alefacept (Amevive) work?

Alefacept (Amevive) is an injectable drug that suppresses the immune system. Scientists believe that psoriasis is produced by a growth in the making of one type of immune cell. It is the T-lymphocytes react to the connection of a stimulant (antigen) to the lymphocyte. The stimulated T-lymphocytes cause skin cells to develop quickly. The fast development of the skin cells that makes the skin plaques of psoriasis. This lessens the stimulation and making of T-lymphocytes. It happens by attaching to the site on the T-lymphocytes where the antigen attaches. This inhibits the antigen from binding and activating the T-lymphocytes. This also decreases the life-span of T-lymphocytes. That already has been made by increasing the activity of another type of immune cell that kills T-lymphocytes.

How to use Alefacept (Amevive)?

The recommended dose for this treatment is 15mg by intramuscular injection. This is usually given once weekly for 12 weeks. The procedure can be repeated after a 12-week interval. It is without treatment if the patient’s T-lymphocyte counts are within the normal range. Do not twice the dose to avoid another complication. Follow your doctor’s prescription promptly. 

What are the side-effects of Alefacept (Amevive)?

  • Chills
  • Muscle pain
  • Itching
  • Nausea
  • Cough
  • Dizziness
  • Sore throat
  • Pain, redness, and swelling at the injection site

If these side effects continue or worsen, call for medical help right away. 

Warnings and Precautions

These are the things that you need to be precautious with while having this treatment:

  • Before taking this, inform your doctor if you have any allergies or current medications.
  • Consult first your doctor if you are pregnant or breastfeeding women.
  • Do not share this with others who have the same symptoms as yours.
  • Keep this away from the reach of children and pets.