Enasidenib

What condition does Enasidenib treat?

Enasidenib is used for the treatment of a certain type of blood cell cancer called acute myeloid leukemia (AML). AML occurs in the myeloid line of blood cells which is categorized by the rapid development of abnormal cells that build up in the bone marrow and blood. It interferes with normal blood cells. This type of condition is typically treated with chemotherapy. This medication will help your bone marrow grow normal blood cells. It is to help you also need a fewer blood transfusions.

Enasidenib is an inhibitor of the isocitrate dehydrogenase-2 (IDH2) enzyme. It comes as a tablet for oral use. Each tablet contains Enasidenib as an active ingredient. The Food and Drug Administration (FDA) has already approved this medicine.

How does Enasidenib work?

Enasidenib is a small molecule inhibitor of the isocitrate dehydrogenase 2 (IDH2) enzymes. It targets the mutant IDH2 variants. Inhibition of the mutant IDH2 enzyme by this drug led to decreased 2-hydroxyglutarate (2-HG) levels. It also leads to an induced myeloid differentiation. This medication lessens 2-HG levels, reduced blast counts, and increased the percentages of mature myeloid cells.

What is the recommended dosage for Enasidenib?

This medicine is to be taken by mouth with a full glass of water. It is usually taken once a day. Swallow the tablet as a whole. Do not break or chew it. You may take each dose with or without food. The recommended dosage is based on your medical condition and response to it.

Remember to take it at the same time and in the same way each day. Take each dose exactly as it is prescribed. Do not increase your dose or use this medication more often or for longer than prescribed. Your illness will not improve any faster, and your risk of certain side effects will increase.

If you vomit after taking a dose, take another dose as soon as possible on the same day. Then take your next dose at the regular time the next day. Do not double the dose to catch up. If you often miss a dose, call your health care provider for details.

What are the side effects of Enasidenib?

  • Nausea
  • Vomiting
  • Diarrhea
  • Changes in taste
  • Decreased appetite

What are the precautions in taking Enasidenib?

  • Before taking each dose, tell your doctor if you are allergic to it. This drug may contain an inactive ingredient that causes an allergic reaction.
  • Drink plenty of liquids while you are taking this medicine.
  • If you are a pregnant or breastfeeding woman, consult your doctor first before taking this drug.
  • Keep using birth control for at least 2 months after your last dose. Tell your doctor right away if a pregnancy occurs.
  • Do not use this drug past the expiration date.
  • You should not share this prescription with others even if they have the same symptoms as yours.
  • Inform your doctor if you have a medical history or current medications.
  • Do not have any type of vaccination or immunization without your doctor’s approval while taking this medicine.
  • Keep this away from the reach of children.