Enbrel (Etanercept) for Injection

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General Information

Enbrel (Etanercept) is indicated to use alone or in combination with an immunosuppressant. This is used to treat certain types of arthritis such as:

  • Psoriatic
  • Juvenile idiopathic
  • Rheumatoid
  • Ankylosing spondylitis

These conditions are caused by an overactive immune system or autoimmune disease. The immune system attacks the body’s own healthy cell that causes inflammation in the joints and skin.

This medication treats but does not cure the condition. The symptoms usually return within a month of stopping the medication.


How does Enbrel (Etanercept) work?

Enbrel (Etanercept) controls your body’s defensive response. It is by blocking the action of a certain natural substance (TNF) that is used by the immune system. Treatment decreases itching, redness, and scaly patches in psoriasis. It also decreases the swelling, pain, and stiffness of joints in arthritis. This medication can stop the progression of the disease and joint damage. It may result in improved daily functioning and quality of life.


Why use Enbrel (Etanercept)?

Enbrel (Etanercept) is in the class of medications called tumor necrosis factor (TNF) inhibitors. This is supplied in a multiple-dose vial as a sterile, preservative-free, white, and lyophilized powder. This is also in the single-dose prefilled syringe. The Food and Drug Administration (FDA) approved this medication.

How to use Enbrel (Etanercept)?

Enbrel (Etanercept) for Injection is given under the skin of the thigh, upper arm, or abdomen. It is usually used once or twice a week. Clean the injection site first with rubbing alcohol before injecting each dose. Change the injection site each time to lessen the injury under the skin.

The dosage is based on your condition and response to the treatment. Do not change the dose without consulting your doctor. Use this medication regularly to get the most benefit from it.

If you are using this at home, learn all the preparation and usage instructions from your doctor. Your doctor may give you the first injection in the medical office.

What are the side-effects of Enbrel (Etanercept)?

  • Vomiting
  • Mild nausea
  • Stomach pain
  • Diarrhea
  • Redness or discomfort at the injection site
  • Weight changes
  • Heartburn
  • Weakness
  • Cold symptoms


Warnings and Precautions

  • You should not receive any vaccinations/immunizations without consulting your doctor.
  • Tell your doctor if you are allergic to it or if you have any allergies. This drug may have inactive ingredients that may cause an allergic reaction.
  • During pregnancy, this should be used only when clearly needed. Discuss with your doctor the risks and benefits.