Esbriet (Pirfenidone)


General Information

Esbriet (Pirfenidone) is indicated for the treatment of a certain lung disease called idiopathic pulmonary fibrosis (IPF). This disease causes the lungs to get scarred and become stiff. It also makes breathing hard. IPF is a long-term disease in which fibrous scar tissue continuously forms in the lungs. It causes persistent cough, frequent ling infection, and severe shortness of breath. This medication may help slow down the worsening of your IPF.


How does Esbriet (Pirfenidone) work?

Esbriet (Pirfenidone) reduces the production of fibroblasts. It also lessens other substances involved in the formation of fibrous tissue during the body’s tissue repair process. Therefore, it slows down the progression of the disease in IPF patients.


Why use Esbriet (Pirfenidone)?

Esbriet Capsule contains Pirfenidone as an active ingredient. This medication belongs to the class of drugs called pyridone. It is available as a white to off-white hard gelatin capsule. It contains 267mg of Pirfenidone for oral administration. It may also be a film-coated tablet containing 534mg and 801mg (brown). The Food and Drug Administration (FDA) already approved this medication.


How to use Esbriet (Pirfenidone)?

The dosage is based on your medical condition, response, and other medications that you are taking.

The dose of this drug is increased steadily, starting with;

  • 267mg three times a day in the first week
  • 534mg three times a day in the second week
  • 801mg three times a day in the third week

It is to be taken by mouth with food as directed by your doctor. Taking it with food may help decrease dizziness and nausea. To lessen the risk of side effects, your doctor may direct you to start at a low dose. To help you remember, take it at the same time each day.


What are the side effects of Esbriet (Pirfenidone)?

  • Headache
  • Tiredness
  • Nausea
  • Dizziness
  • Decreased or loss of appetite
  • Vomiting
  • Stomach upset or pain
  • Weight loss
  • Diarrhea
  • Heartburn
  • Rash
  • Insomnia
  • Fatigue
  • Joint pain
  • Cold symptoms (Stuffy or runny nose and sore throat)


Warnings and Precautions

  • Before taking this drug, let your doctor know if you have any allergies or if you are allergic to this drug. This may contain inactive ingredients that may cause an allergic reaction.
  • Tell also your doctor if you have any medical history or current medications/treatments.
  • This may make you more sensitive to the sun. Use sunscreen and wear protective clothing when outdoors.
  • Consult your doctor first before breastfeeding. This may also not be prescribed in pregnant women.