General Information

Linaclotide is indicated for the treatment of:

  • Chronic idiopathic constipation
  • Irritable bowel syndrome constipation

These conditions are certain types of bowel problems. These have symptoms of difficult and incomplete bowel movements. These also have the symptom of abdominal pain. Linaclotide may improve stool texture and lessen some symptoms such as:

  • Feelings of incomplete bowel movements
  • Abdominal discomfort
  • Bloating

How does Linaclotide work?

Linaclotide works locally in the intestine. It is to increase bowel movements and lessen the pain. The effect of this drug is due to an increase in the production of a chemical called cyclic guanosine monophosphate. That it increases fluid secretion into the intestine and lessens the sensitivity of pain-sensing nerves.

Why use Linaclotide?

Linaclotide is a guanylate cyclase-C agonist. This is also a 14-amino acid peptide. This medication increases fluid in your intestines and helps speed up the movement of food through the gut. Linaclotide is supplied as a capsule that is approved by the Food and Drug Administration (FDA). This is available in the strengths of 72 mcg, 145 mcg, and 290 mcg for oral use.

How to use Linaclotide?

This is to be taken by mouth usually once a day. You may take it at least 30 minutes before your first meal of the day. Swallow the medicine as a whole with a full glass of water. Do not break or chew the capsule.

The dosage is based on your medical condition and response to it. For the best benefit from this, take it regularly. Remember to take each dose at the same time every day. Do not take more or less than the prescription of your doctor. It is very important that you take this medication exactly as it is given.

What are the side effects of Linaclotide?

Common side effects:

  • Gas
  • Bloating
  • Vomiting
  • Heartburn
  • Headache
  • Diarrhea
  • Abdominal or stomach pain
  • Cold symptoms such as sneezing, stuffy nose, or sinus pain

Warnings and Precautions

  • Before using this drug, tell your doctor if you have any allergies. Tell also if you are taking herbal products or vitamins.
  • Inform your doctor if you have an intestinal or stomach blockage.
  • Do not share this with others even they have the same symptoms as yours.
  • This may not be recommended for breastfeeding women or pregnant women.
  • If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your dosing schedule.