General Information
Naloxegol is used to treat constipation caused by narcotic medications. This is usually in people with ongoing pain that is not caused by cancer. This blocks certain effects of opioid medication. Constipation is infrequent bowel movements or difficult passages of stools that persist for several weeks.
How does Naloxegol work?
Naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract. Therefore it lessens the constipating effects of opioids. Naloxegol works quickly within 6-12 hours of the first dose.
Why use Naloxegol?
Naloxegol belongs to a class of drugs called narcotic antagonists. This lessens constipation caused by narcotic medicine. Naloxegol treats constipation without lessening the pain-relieving effects of the narcotic. This medication is supplied as tablets for oral use. Each tablet contains Naloxegol with the strengths of 12.5 mg and 25 mg. This is a prescription approved by the Food and Drug Administration (FDA).
How to use Naloxegol?
The recommended dosage is based on your medical condition, age, and response. For children, the dosage is based also on their weight. It is very important that you take this medication exactly as it is prescribed. Do not increase your dose or use this drug more often or for longer than given.
Naloxegol is usually taken once a day in the morning on an empty stomach. It is taken an hour before or 2 hours after a meal. Take this medication by mouth as directed by your doctor. Swallow the tablet as a whole with a full glass of water. Do not chew or break the medicine. Drink plenty of fluid while having this treatment. Remember to take it in the same way and at the same time every day. Let your doctor know if your condition does not improve or if it gets worse.
What are the side effects of Naloxegol?
- Stomach or abdominal pain
- Nausea
- Diarrhea
- Vomiting
- Headache
- Gas
- Anxiety
- Increased or excessive sweating
- Chills
- Yawning
Warnings and Precautions
- Before taking this medicine, tell your doctor if you are allergic to it. Tell also if you have any medical history or current medications.
- While having this treatment, avoid eating grapefruit or drinking grapefruit juice. It may increase the chance of side effects with this drug.
- Tell your doctor if you have ever had stomach cancer, liver or kidney disease.
- This is not recommended if you have a blockage in your stomach or intestines.
- Do not breastfeed if you are taking Naloxegol.
- Let your doctor know if you are pregnant or planning to become pregnant.
