General Information

Panhematin (Hemin) is used to treat the symptoms that happen with certain blood disorders called porphyrias. It refers to a group of disorders that result from a build-up of natural chemicals. It may produce porphyrin in your body.

This medication is not a cure for porphyria. For some cases, this drug may relieve symptoms of high blood pressure, rapid heartbeat, or pain. It may also relieve mental changes that may occur during an acute attack of porphyria.

How does Panhematin (Hemin) work?

Panhematin (Hemin) inhibits the enzyme (delta)-aminolevulinic acid synthetase. In normal patients, it inhibits this enzyme. It also limits the rate of the porphyrin pathway. Administration of it results in effects, limits the hepatic, and marrow synthesis of porphyrin.

The exact mechanism by which this drug improves symptoms in patients with acute episodes of the hepatic porphyrias is not yet known. This treatment is intended to prevent an attack from reaching the critical stage of neuronal degeneration.

Why use Panhematin (Hemin)?

Panhematin contains Hemin as an active ingredient. It is an iron-containing porphyrin. It is an enzyme inhibitor derived from processed red blood cells. It is a sterile and lyophilized powder suitable for intravenous administration. Each vial has the equivalent of 313 mg hemin, 215 mg sodium carbonate, and 300 mg of sorbitol. The Food and Drug Administration (FDA) has already approved this medication.

How to use Panhematin (Hemin)?

The recommended dosage is based on your medical condition and response to it. It is important to take it exactly as it is prescribed. Remember to take it in the same way and at the same time each day.

It is given by injection into a vein usually once a day. It should only be given in a hospital or clinic where you can be monitored closely.

What are the side-effects of Panhematin (Hemin)?

• Swelling, irritation, or pain at the injection site
• Easy bleeding or bruising
• Little or no urinating
• Rapid weight gain
• Swelling
• Feeling short of breath

Warnings and Precautions

• Call your doctor right away if there are signs of an allergic reaction.
• Tell your doctor if you have any medical history or current medications.
• If you are pregnant or breastfeeding women, consult your doctor first before using this medication.
• Let your doctor know if you are allergic to this drug.
• This medication is given in a hospital and will not be stored at home.