Tolvaptan

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What condition does Tolvaptan treat?

Tolvaptan is used for the treatment of low levels of salt or sodium in the blood which may lead to certain conditions such as hormone imbalance and heart failure. Too much hormone can cause an imbalance that results in fluid retention and low sodium levels. This medication helps to slowly increase to normal levels of salt in the blood.

This medicine is selective and competitive arginine vasopressin receptor-2 antagonists. This is supplied as an immediate-release tablet for oral use. The Food and Drug Administration (FDA) has already approved this medication.

How does Tolvaptan work?

Tolvaptan acts on the V2 receptors found in the walls of the vasculature and luminal membranes of renal collecting ducts. By blocking V2 receptors in the renal collecting ducts, aquaporins do not insert themselves into the walls. Thus, it prevents the absorption of the water.

This action results in decreased urine osmolality, an increase in urine volume, and increase electrolyte-free water clearance. It is to lessen the intravascular volume and increase serum sodium levels. Tolvaptan is especially useful for heart failure patients as they have higher serum levels of vasopressin.

What is the recommended dosage for Tolvaptan?

Tolvaptan is to be taken by mouth usually once a day. You may take each dose with or without a meal. Remember to take it at the same time each day. You should take this medicine for longer than 30 days. To prevent losing too much body water, always have water ready to drink while taking this medicine. Drink when you are thirsty unless otherwise directed by your doctor.

The dosage is based on your medical condition and response to the treatment. Do not take more than the prescription. You must take it exactly as it is prescribed. Remember that your doctor has prescribed this medicine because they have judged that the benefit to you is greater than the risk of side effects. Lots of people using this medicine do not have serious side effects.

What are the side effects of Tolvaptan?

  • Feeling unwell
  • Dry skin
  • Rash
  • Decreased appetite
  • Dizziness
  • Nighttime urination
  • Increased urination both in volume and frequency
  • Nausea
  • Thirst
  • Vomiting
  • High uric acid in the blood
  • Indigestion
  • Heart palpitation

What are the precautions in taking Tolvaptan?

  • Do not suddenly stop or change the dose of this medication without consulting your doctor.
  • Inform your doctor if you have any allergies before taking this medicine.
  • You should not eat grapefruit or drink grapefruit juice while having this medicine.
  • If you are a pregnant or breastfeeding woman, talk to your doctor first.
  • Tell your doctor if you have or have ever had a high level of potassium in your blood.
  • This medicine may rarely make your blood sugar rise, which can cause or worsen diabetes. If you have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor might need to change your diabetes medication, exercise program, or diet.
  • Keep this far from heat and moisture to avoid some contaminations.