General Information

Trametinib is indicated for the treatment of skin cancer called melanoma. This is used with other medications such as Dabrafenib. Melanoma is a type of cancer that develops from the pigment-containing cells known as melanocytes. It typically occurs in the skin but may rarely occur in the mouth, eye, or intestines.

Trametinib may also be used together with Dabrafenib to treat thyroid cancer and non-small cell lung cancer (NSCLC).

How does Trametinib work?

Trametinib blocks the activity of a protein called MEK. It is a molecule that helps regulate cell growth. MEK is part of a signaling pathway that includes BRAF and another protein. A BRAF mutation signals cells develop abnormally and divide out of control. These cells grow into a melanoma tumor.

Trametinib acts on melanomas that have the V600E or V600K mutations in the BRAF protein. The medication interferes with abnormal BRAF signals to slow or stop the out-of-control cell growth.

Why use Trametinib?

Trametinib is in the class of medications called kinase inhibitors. This blocks the action of some unusual protein that signals cancer cells to grow. This will also help stop the spread of cancer cells. Trametinib is a prescription approved by the Food and Drug Administration (FDA). This is supplied as tablets for oral use. Each tablet is available in the strengths of 0.5 mg and 2 mg.

How to use Trametinib?

The recommended dosage is based on your medical condition, age, and response. This is to be taken by mouth as directed by your doctor. It is important that you take this exactly as it is prescribed.

Trametinib is usually taken once a day. It is to be taken 2 hours after or at least an hour before a meal. Swallow the tablet as a whole with a full glass of water. Do not increase the prescribed dosage or take it more often. Remember to take it at the same time each day.

What are the side effects of Trametinib?

  • Acne
  • Itching
  • Dry skin
  • Rash
  • Diarrhea
  • Abdominal pain
  • Fever
  • Chills
  • Tiredness
  • Headache
  • Cough
  • Constipation
  • Muscle or joint pain
  • Dizziness
  • Changes in taste
  • Blurred vision
  • Dry eyes

Warnings and Precautions

  • You should know that this medication may decrease fertility in women. Talk to your doctor about the risks of taking Trametinib.
  • Do not use this if you are allergic to it. Tell your doctor if you have any allergies.
  • Let your doctor know about the medical history that you had. Tell also if you have any current medications.
  • Consult your doctor first if you are pregnant or breastfeeding women before taking Trametinib.